The phosphine ligand is available on the kilo scale for the first time, providing scientists with a powerful solution for cross-coupling chemistry.

Advanced homogeneous catalysts and ligands producer, Sinocompound Catalysts Co., Ltd, has made phosphine-based QPhos ligand available in kilogram quantities for commercial use.

With this ligand now accessible on a large scale, scientists can incorporate QPhos-based catalysts in their drug discovery, screening and process development programs to optimise and streamline product development.
Pharmaceutical companies invest significantly in drug development to optimise product synthesis and expedite market innovations.

QPhos is a promising ligand in metal-catalyzed cross-coupling reactions, which are fundamental to construct carbon-based bonds featured in most drug scaffolds. However, until now QPhos has not been readily available in commercial quantities, hindering its adoption in process development and scale-up programs.
“There’s an enormous amount of untapped potential in ligands that scientists simply can’t access on a large scale, so they discount them from their screening programs,” explains Dr Carin Seechurn, Associate Director – Technology Solutions, Sinocompound.

“Our capability to scale-up the QPhos ligand represents a significant milestone in improving ligand accessibility for researchers. As we continue to expand our manufacturing processes, we’re excited to provide more overlooked ligands and products commercially.”

QPhos is a robust dialkylarylphosphine ligand developed by Professor John Hartwig for metal-catalysed cross-coupling reactions¹. Bulky and electron-rich, it performs excellently in many transformations including α-arylation of carbonyl compounds and late-stage C-C bond formation.
For more information on Sinocompound’s scalable ligand development solutions, visit